Genetics and Ethnicity
“There was a significant interaction between race and dosing strategy.” This is a quote from Kimmel et al’s 2013 paper on warfarin dosing and while race is a relatively small point compared to the major findings of their paper (which we discuss here), this quote hints to a larger point of interest. When it comes to personalized medicine, ethnicity matters.
We’re just beginning to understand what impact ethnicity has on disease. Certain genetic variants can be common in one population, but nearly absent in another. For example, a paper from 2007 suggests that patients of Asian ancestry might be at high risk for CYP2C19 variations. As the field of pharmacogenetics grows, we expect to see more and more papers examining how ethnicity can affect drug metabolism.
Ethnicity is a fundamental element of personalized medicine. The more we learn, the more we see that populations are really a mosaic, not a homogenous mixture. Click here to learn more about pharmacogenetic testing.