• Skip to primary navigation
  • Skip to main content
  • Skip to footer
Invitae | Genelex

Invitae | Genelex

Pharmacogenetics Makes Precision Medicine Possible

  • For Patients
    • Conditions
    • Affected Drugs
    • What is PGx?
    • Resources
    • FAQs
  • For Providers
    • Conditions
    • Resources
    • Order Testing Supplies
  • Test Menu
  • Clinical Trials
  • About
    • Lab Accreditations
    • Genelex Team
    • Contact Us
  • Log In

How Common are Drug and Gene Interactions?

Home / Press Releases / How Common are Drug and Gene Interactions?

Genelex Blog

How Common are Drug and Gene Interactions?

The CDC and Journal of the American Medical Association report that adverse drug reactions are a major health issue in America, costing billions of dollars a year and affecting millions of patients. Many of these are the typical drug-drug interactions (DDI) that most EHRs and e-prescribing systems can catch. However, typical DDI programs miss drug-gene interactions (DGI’s). Only YouScript® can detect both DDI’s and DGI’s. And only YouScript can find their combined effect — the drug-drug-gene interactions.

Drug-drug-gene interactions (DDGI’s) happen to drugs which have two or more metabolic pathways when one pathway is reduced by a genetic mutation and the other pathway is blocked by an inhibiting drug.

But how common are DGI’s and DDGI’s? Until now, the prevalence of DGI’s and DDGI’s compared to DDI’s hasn’t been examined. But a new paper is now being published by the journal, Pharmacogenomics.

Titled How common are drug and gene interactions? Prevalence in a sample of 1143 patients with CYP2C9, CYP2C19 and CYP2D6 genotyping, the paper shows that typical DDI programs may miss more than a third of all potentially clinically significant interactions.

The paper, written by Genelex’s P. Verbeurgt, T. Mamiya, and J. Oesterheld, will be published this April in Pharmacogenomics, Issue 15 (Volume 5).

Genelex Resources

Affected Conditions
Affected Drugs
Info for Providers
Frequently Asked Questions
Contact Genelex
Join Our Mailing List

Footer

CONTACT US

(800) 837-8362
info@genelex.com

3101 Western Ave.
Suite 100
Seattle, WA 98121

HELPFUL INFORMATION

What is PGx?
Test Menu
Conditions
Affected Drugs
FAQs
References

ABOUT GENELEX

Blog
News
Genelex Team
Lab Accreditations
Contact Us
Privacy Practices
Privacy Policy

  • Facebook
  • LinkedIn
  • RSS
  • Twitter
  • YouTube

KEEP IN TOUCH

Stay in the loop with news and updates from Genelex and be among the first to know when new tests become available.