• Skip to primary navigation
  • Skip to main content
  • Skip to footer
Invitae | Genelex

Invitae | Genelex

Pharmacogenetics Makes Precision Medicine Possible

  • For Patients
    • Conditions
    • Affected Drugs
    • What is PGx?
    • Resources
    • FAQs
  • For Providers
    • Conditions
    • Resources
    • Order Testing Supplies
  • Test Menu
  • Clinical Trials
  • About
    • Lab Accreditations
    • Genelex Team
    • Contact Us
  • Log In

Tamoxifen and CYP2D6 Interactions

Home / News / Tamoxifen and CYP2D6 Interactions

Genelex Blog

Tamoxifen and CYP2D6 Interactions

medicineCYP2D6 gene testing for personalizing tamoxifen therapy has been a source of confusion and debate for over a decade. In addition to conflicting outcomes data on breast cancer recurrence rates in women with deficient CYP2D6 enzyme activity (i.e., CYP2D6 Intermediate and Poor Metabolizers) treated with tamoxifen, significant controversy exists around the methodology for using tumor cell DNA to estimate the phenotype rather than germline DNA. Excellent commentary on this can be read by accessing this article and reading the open access commentaries.

It is important to note that the National Comprehensive Cancer Network (NCCN) and American Society of Clinical Oncology (ASCO) do not recommend CYP2D6 testing as a tool to determine the optimal adjuvant endocrine strategy. However, both groups do caution about the coadministration of tamoxifen with potent CYP2D6 inhibitors.

See the following articles in for more information on the CYP2D6-tamoxifen controversy:

JAMA. 2009 Oct 7;302(13):1429-36.

J Natl Cancer Inst. 2012 Mar 21;104(6):441-51.

J Natl Cancer Inst. 2012 Mar 21;104(6):452-60.

Genelex Resources

Affected Conditions
Affected Drugs
Info for Providers
Frequently Asked Questions
Contact Genelex
Join Our Mailing List

Footer

CONTACT US

(800) 837-8362
info@genelex.com

3101 Western Ave.
Suite 100
Seattle, WA 98121

HELPFUL INFORMATION

What is PGx?
Test Menu
Conditions
Affected Drugs
FAQs
References

ABOUT GENELEX

Blog
News
Genelex Team
Lab Accreditations
Contact Us
Privacy Practices
Privacy Policy

  • Facebook
  • LinkedIn
  • RSS
  • Twitter
  • YouTube

KEEP IN TOUCH

Stay in the loop with news and updates from Genelex and be among the first to know when new tests become available.