Genelex Blog Genetic Guidance of Warfarin Dosing Shows Promise from Heartwire - Sue Hughes November 7, 2007 (Orlando, FL) – Using genetic tests as well as clinical factors improved the accuracy and efficiency of warfarin dose initiation, but the primary end point of a reduction in out-of-
Metabolic Polymorphisms and Cancer Susceptibility
Genelex Blog Metabolic Polymorphisms and Cancer Susceptibility The vast majority of cancers arise as a consequence of exposure to environmental agents that are toxic or mutagenic. In response to this, all higher organisms have evolved complex mechanisms by which they can protect themselves
Contributions of CYP2C9/CYP2C19 genotypes and drug interaction to the phenytoin treatment in the Korean epileptic patients in the clinical setting
Genelex Blog Contributions of CYP2C9/CYP2C19 genotypes and drug interaction to the phenytoin treatment in the Korean epileptic patients in the clinical setting We examined the contribution of CYP2C9 and CYP2C19 genotypes and drug interactions to the phenytoin metabolism among 97 Korean
Drug interactions and pharmacogenetic reactions are the basis for chloroquine and mefloquine-induced psychosis
Genelex Blog Drug interactions and pharmacogenetic reactions are the basis for chloroquine and mefloquine-induced psychosis BACKGROUND - Chloroquine and mefloquine used for prophylaxis and treatment of malaria sometimes causes severe mental status changes,including psychosis, through
The influence of NSAIDs on coumarin sensitivity in patients with CYP2C9 polymorphism after total hip replacement surgery
Genelex Blog The influence of NSAIDs on coumarin sensitivity in patients with CYP2C9 polymorphism after total hip replacement surgery OBJECTIVE - To determine the influence of NSAIDs on the international normalized ratio (INR) in patients with cytochrome P450 (CYP)-2C9 enzyme variants