Many drugs are known to metabolize poorly in people with certain genetic variations. Specifically, more than 250 of the most commonly prescribed medications that are used to treat a variety of conditions, are recognized by the FDA as being susceptible to genetic-driven impacts.  And, we know that nearly 90% of the population has at least one genetic variation that may affect their response to medications.
When you take a drug or are exposed to an environmental toxin, enzymes in your body get to work to break down that drug so it can be excreted.
Differences in how enzymes break down drugs can mean that people need different doses of a particular drug to achieve the same effect, or that some drugs might not be as effective for them. Many of these gene variations are very common in the general population and can affect decisions about the right drug or right drug dose.
Common Drugs Impacted by Genetics
Thousands of medications are affected by genetics — not all drugs provide the same results, and by understanding genetics, we can better understand what medication may work before you take it. Over 250 of the most commonly prescribed medications are so susceptible to these genetic-driven impacts that the FDA has issued a warning/guidance on their medication labels.
Fluorouracil (5-FU) is one of the most successful and widely used chemotherapy drugs. It is often used in the treatment of breast, colon, and skin cancer (three of the most frequently occurring cancers). In general, 5-FU is relatively well tolerated at standard doses. However, an estimated 3-8% of patients have a genetic variation that is crucial for the metabolism and deactivation of 5-FU. [Read more]
The FDA requires a black box warning on Plavix labeling to advise physicians of the importance of genetics and the availability of testing. In recent, landmark studies, researchers have found that patients with variations in a gene called cytochrome P-450 2C19 (CYP2C19) have a 3.58 times greater risk for major adverse cardiovascular events such as death, heart attack, and stroke; the risk was greatest in CYP2C19 poor metabolizers. [Read more]
Tamoxifen is a medication for the treatment of breast cancer or for people at a high risk of developing breast cancer.
Recent research has shown that women with breast cancer may not receive the full medical benefit from taking tamoxifen due to their unique genetic make-up. These women have a version of a gene called Cytochrome P450 2D6, which reduces the effectiveness of tamoxifen and increase their chance of breast cancer recurrence. [Read more]
According to the FDA, hemorrhage during warfarin therapy is a leading cause of death in Western countries and related adverse events account for 1 in 10 hospital admissions. Recent discoveries in DNA research make predicting the dose of warfarin a person needs much more accurate and can reduce the risk of adverse drug events. [Read more]
Take a Risk Assessment
Simply enter the medications you’re currently on or plan to take. Click “Get Results” to see if your regimen puts you at risk for an adverse drug reaction.
YOUR GENELEX RISK ASSESSMENT RESULTS: