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Home / Patients / Affected Drugs / Tramoxifen

AFFECTED DRUGS: TRAMOXIFEN

Cytochrome P450 2D6 Testing for Tamoxifen Resistance

Fluorouracil

Plavix

Tamoxifen

Strattera

Warfarin

Additional Drugs

Tamoxifen is a medication for the treatment of breast cancer or for people at a high risk of developing breast cancer.

Recent research has shown that women with breast cancer may not receive the full medical benefit from taking tamoxifen due to their unique genetic make-up.[21] These women have a version of a gene called Cytochrome P450 2D6, which reduces the effectiveness of tamoxifen and increases their chance of breast cancer recurrence.

Since more than 25% of all clinically used medications are metabolized by 2D6, knowing your 2D6 status may help you and your doctor with the future selection of medications and doses[33]

This test looks at a specific gene, called CYP2D6, to determine whether your body can fully metabolize tamoxifen to its active form, endoxifen.

Who Should Be Tested

The CYP2D6 test for tamoxifen is considered appropriate for women who are taking tamoxifen for breast cancer or for those considering taking tamoxifen to prevent the recurrence of breast cancer. It is especially important if the patient is also taking or considering co-administration with selective serotonin reuptake inhibitors (SSRIs).

Improving Drug Efficacy

Genelex's pharmacogenetic testing bridges the gap in understanding how the role of PGx can help in patient care and offers a simple DNA test and provides you with a report of the results that you and your doctor can discuss.

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