Almost one-third of Americans currently take antidepressant medications. Despite the number of antidepressants available, up to 30% of patients do not respond to their first antidepressant medication. Research shows that of all the clinical factors that alter a patient’s response to drugs (such as age, sex, weight, general health, and liver function), genetics play a primary role.
Virtually all medications used to treat depression are metabolized by two enzymes in the liver: CYP2D6 and CYP2C19. Other metabolic pathways include CYP1A2, CYP2B6, CYP3A4, COMT, GRIK4, HTR2A, HTR2C and MTHFR.
Your genes are the main factor in determining the level of these enzymes in your liver. If you have too much of the enzyme, you process the medication too quickly, too little of the enzyme and the medication builds up in your bloodstream potentially causing adverse reactions or side effects. Without knowing your genetics, your physician may need to go through months of trial-and-error prescribing to find the right drug and dose for you.
PGx AND DEPRESSION
Discover the Right Treatment for Depression, Faster
Over the last decade, significant advancements in pharmacogenetics or “personalized medicine” have provided alternative methods for selecting drugs based on a patient's unique genetic profiles. Pharmacogenetics has been successfully used to optimize the selection and dosing of depression medications, as well as helping to avoid adverse effects.
Genelex pharmacogenetic testing complements current efforts to optimize treatment of depressions and leads towards effective and personalized care — all while being more cost effective and reducing trial-and-error efforts.
With advances in genetics, you are now able to optimize your response to depression and other psychiatric medications through DNA testing. In partnership with YouScript, a leader in drug-drug and drug-gene interaction software, you'll get a report highlighting patient-specific genetic markers and potential interactions, allowing for drug and dosage decisions to be catered to your needs.
Population Frequency of Cytochrome P450 Metabolizer Types 
|Poor (no or low enzyme levels)||Intermediate (reduced enzyme levels)||normal (normal enzyme levels)||Rapid or Ultra Rapid (high enzyme levels)|
*CYP2C19 variability depends on ethnicity.
*CYP2D6 Variability depends on ethnicity and classification of Intermediate activity
Additional psychiatric medications that are impacted by your genetics:
Take a Risk Assessment
Simply enter the medications you’re currently on or plan to take. Click “Get Results” to see if your regimen puts you at risk for an adverse drug reaction.
YOUR GENELEX RISK ASSESSMENT RESULTS: