More than 29 million people in the United States have diabetes [10]. As such, millions of Americans currently take diabetes medication.
Your genes are the main factor in determining the level of these enzymes primarily found in your liver — if you have too much of the enzyme, you process the medication too quickly, too little of the enzyme and the medication builds up in your bloodstream potentially causing adverse reactions or side effects.
PGx AND DIABETES
Learn How Diabetes, Genetics, and Medications Work Together
Pharmacogenetic testing complements current efforts to optimize personalized care in diabetes patients— all while being more cost effective and reducing trial-and-error efforts.
Population Frequency of Cytochrome P450 (CYP) Metabolizer Types [3]
| Poor (no or low enzyme levels) |
Intermediate (reduced enzyme levels) |
Normal (normal enzyme levels) |
Rapid or Ultra Rapid Metabolizer (high enzyme levels) |
|
|---|---|---|---|---|
| CYP2C9 | 3% | 30% | 68% | N/A |
| CYP2C19 | 2-20% | 24-36% | 14-44% | 30% |
*CYP2C19 variability depends on ethnicity.
*CYP2D6 Variability depends on ethnicity and classification of Intermediate activity