Genetic factors contribute to the high inter-individual variability in response to anti-epileptic drugs. Precision medication management, including DNA testing, is extremely important for the proper treatment of epilepsy — finding the right drug and dose is vital.
Other metabolic pathways include CYP3A4, CYP3A5, HLA-B*15:02, HLA-A*31:01 and UGT1A1.
Your genes are the main factor determining the level of these enzymes in your liver — if you have too much of the enzyme, you process the medication too quickly, too little of the enzyme and the medication builds up in your bloodstream potentially causing adverse reactions or side effects.
Without knowing your genetics, your physician may need to go through months of trial-and-error prescribing to find the right drug and dose for you.
PGx AND EPILEPSY
Discover the Right Treatment for Epilepsy, Faster
Genelex pharmacogenetic testing complements current efforts to optimize treatment of epilepsy and leads towards effective and personalized care — all while being more cost effective and reducing trial-and-error efforts.
Over the last decade, significant advancements in pharmacogenetics or “personalized medicine” have provided alternative methods for selecting drugs based on a patient's unique genetic profiles. Pharmacogenetics has been successfully used to optimize the selection and dosing of anti-epileptic medications, as well as helping to avoid adverse effects.
Given these advances, you are now able to optimize your response to common anti-epileptic medication through DNA testing. In partnership with YouScript, a leader in drug-drug and drug-gene interactions, you'll get a report highlighting potential interactions, allowing for drug and dosage decisions to be catered to your needs.
Population Frequency of Cytochrome P450 (CYP) Metabolizer Types [5]
| Poor (no or low enzyme levels) |
Intermediate (reduced enzyme levels) |
Normal (normal enzyme levels) |
|
|---|---|---|---|
| CYP2C9 | 3% | 30% | 68% |
| CYP2C19* | 3%-21% | 24-36% | 79-97% |
*CYP2C19 variability depends on ethnicity.
Some epilepsy medications that are impacted by your genetics: [12]
| Trade Name | DRUG |
|---|---|
| Aptiom® | eslicarbazepine-acetate |
| Banzel® | rufinamide |
| Briviact® | brivaracetam |
| Cerebyx® | fosphenytoin |
| Depakote | valproic acid |
| Dilantin® | phenytoin |
| Felbatol® | felbamate |
| Flexeril® | cyclobenzaprine |
| Fycompa® | perampanel |
| Gabitril® | tiagabine |
| Keppra® | levetiracetam |
| Lamictal® | lamotrigine |
| Lyrica® | pregabalin |
| Mysoline® | primidone |
| Neurontin® | gabapentin |
| Potiga® | ezogabine |
| Sabril® | vigabatrin |
| Tegretol® | carbamazepine |
| Tercian® | cyamemazine |
| Topamax® | topiramate |
| Trileptal® | oxcarbazepine |
| Vimpat® | lacosamide |
| Zarontin® | ethosuximide |
| Zonegran® | zonisamide |
Patient Resources
Take a Risk Assessment
Simply enter the medications you’re currently on or plan to take. Click “Get Results” to see if your regimen puts you at risk for an adverse drug reaction.
YOUR GENELEX RISK ASSESSMENT RESULTS: