HIV therapy is known to be associated with a large variability in efficacy and toxicity among different individuals even at standard doses. Reasons for this large inter-individual variability are attributed to race, gender, concomitant medications, drug compliance, underlying diseases, and genetic factors.
More than half of all medications including the majority of HIV medications are metabolized by three enzymes in the liver: CYP2D6, CYP2C9, and CYP2C19. Other metabolizing pathways include CYP2B6, CYP3A4, HLA-B*57:01, SLCO1B1, and UGT1A1.
Your genes are the main factor determining the level of these enzymes in your liver — if you have too much of the enzyme, you process the medication too quickly, too little of the enzyme and the medication builds up in your bloodstream potentially causing adverse reactions or side effects. Without knowing your genetics, your physician may need to go through months of trial-and-error prescribing to find the right drug and dose for you.
PGx AND HIV THERAPY
Discover the Right Therapy for HIV, Faster
Genelex pharmacogenetic testing complements current efforts to optimize treatment of HIV and leads towards effective and personalized care — all while being more cost effective and reducing trial-and-error efforts.
With advances in genetics, you are now able to optimize your response to HIV drugs and many other medications through DNA testing. In partnership with YouScript, a leader in drug-drug and drug-gene interaction software, you'll get a report highlighting patient-specific genetic markers and potential interactions, allowing for drug and dosage decisions to be catered to your needs.
Population Frequency of Cytochrome P450 (CYP) Metabolizer Types 
(no or low enzyme levels)
(reduced enzyme levels)
(normal enzyme levels)
(high enzyme levels)
*CYP2C19 variability depends on ethnicity.
*CYP2D6 Variability depends on ethnicity and classification of Intermediate activity
Take a Risk Assessment
Simply enter the medications you’re currently on or plan to take. Click “Get Results” to see if your regimen puts you at risk for an adverse drug reaction.
YOUR GENELEX RISK ASSESSMENT RESULTS: