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Home / Patients / Conditions / Ulcers/Acid Reflux

FOR PATIENTS

Pharmacogenetics and Acid Reflux

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Acid Reflux

Millions of Americans currently take acid reflux or ulcer medications.

Over half of all medications including many acid reflux and ulcer medications, such as Prilosec® (omeprazole) and Nexium® (esomeprazole), are metabolized by two enzymes found primarily in the liver called CYP3A4 and CYP2C19.[1,18] 

Your genes are the main factor in determining the level of these enzymes in your liver — if you have too much of the enzyme, you process the medication too quickly, too little of the enzyme and the medication builds up in your bloodstream potentially causing adverse reactions or side effects.

PGx AND ULCERS/ACID REFLUX

Learn How Acid Reflux, Genes, and Drugs Work Together

Over the last decade, significant advancements in pharmacogenetics or “personalized medicine” have provided alternative methods for selecting drugs based on a patient's unique genetic profiles.

Our pharmacogenetic test includes analysis with drug-drug and drug-gene interaction software, and you'll get a report highlighting potential interactions to discuss with your healthcare provider.

Population Frequency of Cytochrome P450 (CYP) Metabolizer Types [5]

Poor 
(no or low enzyme levels)
Intermediate(reduced enzyme levels) Normal (normal enzyme levels) Rapid or Ultra Rapid Metabolizer(high enzyme levels)
CYP2C9 3% 30% 68% N/A
CYP2C19* 2-20% 24-36% 14-44% 30%

*CYP2C19 variability depends on ethnicity.

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Improving Drug Efficacy

Genelex's pharmacogenetic testing bridges the gap in understanding how the role of PGx can help in patient care and offers a simple DNA test and provides you with a report of the results that you and your doctor can discuss.

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