Understanding Your Results
Pharmacogenetic testing provides information about your genes and gives your provider insight into your current medication regimen.
Congratulations! You have just received pharmacogenetic testing results to help determine how your genes may affect the way your body processes prescribed medications, herbals, over-the-counter and recreational drugs.
The next step is to review your test results with your healthcare provider. Based on your unique genetic characteristics, and with the help of your patient-friendly report, your doctor will be able to use this to help inform decision-making in prescribing drugs that are safe and effective for you.
Going forward, it is important that you share with all your healthcare providers the patient cards that came with your results. This information should be reviewed anytime medication changes are considered, to help keep you provider aware. You should not make any changes to your medications without consulting with your healthcare provider(s).
Your wallet card lists the most important genes, those that belong to the CYP450 family. Just a few of the many CYP450 enzymes do most of the work required to metabolize the drugs we take. After a drug is metabolized, it is eliminated from the body. These enzymes are extremely important because the effect they have on drugs may change. Approximately 90% of Americans have genetic variations in these CYP enzymes that influence how drugs are metabolized.
These enzymes, plus other genes affecting drug response, have been identified. The results of pharmacogenetic testing will not change in your lifetime. Each enzyme that was tested is categorized as follows:
|Metabolizer Phenotype||Enzyme Activity|
|Normal Metabolizer||A normal-metabolizing enzyme may generally break down standard doses of a drug.|
|Intermediate Metabolizer||An intermediate-metabolizing enzyme is considered to be less active. It doesn't break down a drug as completely as a normal metabolizer, which means you might require a lower dose. A lower dose prevents the unmetabolized drug from building up in your body and possibly causing side effects.|
|Poor Metabolizer||A poor-metabolizing enzyme has very low activity. It is possible to have side effects even with a very low drug dose, because the enzyme is very slow to break down the drug.|
|Rapid or Ultrarapid Metabolizers||These enzymes are very active, often breaking down drugs before they can have any effect. If you metabolize a drug in this way, you may require a higher dose in order for the drug to work properly.|
Your genetic profile plus your medication list will be reviewed by a licensed pharmacist and your report details may contain information about drug-drug, FDA approved drug-gene interactions. In addition to your patient-friendly report, your provider will receive a physician report, giving them evidence-based medication or dose change guidance for all significant warnings.
Discuss this information with your doctor. You can send us a message or call 800-TEST-DNA if you still have questions on what your results mean. Pharmacists are here to help.