Understanding Your Results
DNA Sensitivity Testing provides countless insights into your health and gives you clinically actionable insight into your current medication regimen and overall wellbeing.
Congratulations! You have just received DNA sensitivity testing powered by YouScript to determine how your genes affect the way your body processes prescribed medications, herbals, over-the-counter and recreational drugs.
The next step will be to review your test results with your doctor. Based on your unique genetic characteristics, and with the help of the YouScript Precision Prescribing System analytics software, your doctor will be able to prescribe drugs that are safe and effective for you.
Going forward, it is important that you share with all your healthcare providers the patient cards that came with your results. This information should be reviewed anytime medication changes are considered, to help select the safest and most effective drug and dose for you. Always consult with your doctor before you start or stop a medication or change how much you take.
Your wallet card lists the most important genes, those that belong to the CYP450 family. Just a few of the many CYP450 enzymes do most of the work required to metabolize the drugs we take. After a drug is metabolized, it is eliminated from the body. These enzymes are extremely important, because the effect they have on drugs can change – sometimes drastically – the effect that drugs have on us. Approximately 85 % of Americans have genetic variations in these CYP enzymes that influence how drugs are metabolized.
These enzymes, plus other genes affecting drug response, have been identified. The YouScript Precision Prescribing System then developed a report to explain how each of your enzymes metabolizes drugs. The results of this test will not change in your lifetime. Each enzyme that was tested is categorized as follows:
|Metabolizer Phenotype||Enzyme Activity|
|Normal Metabolizer||A normal-metabolizing enzyme can generally break down standard doses of a drug.|
|Intermediate Metabolizer||An intermediate-metabolizing enzyme is considered to be less active. It doesn't break down a drug as completely as a normal metabolizer, which means you might require a lower dose. A lower dose prevents the unmetabolized drug from building up in your body and possibly causing side effects.|
|Poor Metabolizer||A poor-metabolizing enzyme has very low activity. It is possible to have side effects even with a very low drug dose, because the enzyme is very slow to break down the drug.|
|Rapid or Ultrarapid Metabolizers||These enzymes are very active, often breaking down drugs before they can have any effect. If you metabolize a drug in this way, you may require a higher dose in order for the drug to work properly.|
In addition to describing how your enzymes metabolize drugs, your report also provides detailed information and prescribing recommendations about each of the drugs you are currently taking. Your genetic profile plus your medication list will have been reviewed by a licensed pharmacist and your report details may contain information about drug-drug, drug-gene interactions, dosage changes, and alternate medications. YouScript prescribing software also alerts your physician, providing evidence-based medication or dose change guidance for all “Contraindicated”, “Major” and “Moderate” warnings.
Discuss this information with your doctor, or you can send us a message or call 800-TEST-DNA if you still have questions on what your results mean. Pharmacists and other support staff are here to help.
Take a Risk Assessment
Simply enter the medications you’re currently on or plan to take. Click “Get Results” to see if your regimen puts you at risk for an adverse drug reaction.
YOUR GENELEX RISK ASSESSMENT RESULTS: