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Home / Providers / Conditions / HIV

FOR PATIENTS

Pharmacogenetics and HIV Therapy

Cancer

Depression

Epilepsy

Cardiovascular

Chronic Pain

Diabetes

HIV

Acid Reflux

HIV therapy is known to be associated with a large variability in efficacy and toxicity among different individuals even at standard doses. Reasons for this large inter-individual variability are attributed to race, gender, concomitant medications, drug compliance, underlying diseases, and genetic factors.

More than half of all medications including the majority of HIV medications are metabolized by three enzymes in the liver: CYP2D6, CYP2C9, and CYP2C19.[16] Other metabolizing pathways include CYP2B6, CYP3A4, HLA-B*57:01, SLCO1B1, and UGT1A1.

Population Frequency of Cytochrome P450 (CYP) Metabolizer Types [5]

Poor 
(no or low enzyme levels)
Intermediate
(reduced enzyme levels)
Extensive
(normal enzyme levels)
Rapid or
Ultra Rapid
Metabolizer
(high enzyme levels)
CYP2D6* 4-7% 9-35% 50-90% 2-3%
CYP2C9 3% 30% 68% N/A
CYP2C19* 2-20% 24-36% 14-44% 30%

*CYP2C19 variability depends on ethnicity.
*CYP2D6 Variability depends on ethnicity and classification of Intermediate activity

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Pharmacogenetic testing bridges the gap in understanding how the role of PGx can help in patient care and offers a simple DNA test that provides you with a physician report of the patient results to help with optimal care.

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