SLC6A4 (5-HTT) Genotyping
Serotonin is a neurotransmitter, a chemical that transmits signals from one nerve cell to another. Changes in the levels of this chemical have been associated with a number of behavioral disorders. Certain psychiatric medications assist in treating these disorders by targeting 5-HTT, a protein that helps naturally regulate serotonin levels. Genetic changes to SLC6A4 (5-HTT) have been shown to decrease the effectiveness of these medications and increase the risk of adverse effects, particularly in Caucasians.  Genetic variants tested for 5-HTTLPR/rs25531 are LA,XLA,SA,SG,LG,XLG.
Indication for 5HTT Testing
Patients who are initiating selective serotonin reuptake inhibitors (SSRIs) or other 5-HTT-targeting therapies. Additionally, testing is recommended for those experiencing adverse effects or low efficacy should consider SLC6A4 (5-HTT) genotyping.
Check with your insurance provider to determine if SLC6A4 (5-HTT) testing and genotyping is covered. CPT Code is 81479 (provided as guidance only).
Click here to order testing supplies or call Client Services at 800-837-8362.
- Buccal Swabs: 4 sterile buccal swabs
- Blood: 5-10cc whole blood lavender-top EDTA or yellow-top ACD-A tubes
- Turnaround Time: 10 business days, faster turnaround available for clinical trials