Cytochrome P-450 1A2 Genotyping
CYP1A2 is part of the cytochrome P450 family of drug-metabolizing enzymes and is responsible for the metabolism of approximately 9% of prescription drugs. An allele is one of the possible forms of a gene, and certain forms have been associated with altered enzyme activity — meaning that your specific form of CYP1A2 could impact how you process and metabolize certain medications. CYP1A2 is known to metabolize common medications, including theophylline (Elixophyllin®), melatonin, clopidogrel (Plavix®), clozapine (Clozaril®), and caffeine. Common genetic alleles tested are *1A,*1C,*1E,*1F,*1J,*1K.
Indications for CYP1A2 Testing
Numerous drug interactions exist with smoking. Patients who smoke and require treatment with clozapine and clopidogrel are often good candidates for CYP1A2 testing, as its efficacy is induced by polycyclic aromatic hydrocarbons, which are found in cigarette smoke. Smokers taking a medication that interacts with cigarette smoke may require higher dosages than nonsmokers. Conversely, upon smoking cessation, smokers may require a reduction in the dosage of an interacting medication.
Check with your insurance to see if CYP1A2 genotyping is covered. CPT Codes is 81479 (provided as guidance only)
Click here to order testing supplies or call Client Services at 800-837–8362.
- Buccal Swabs: 4 sterile buccal swabs
- Blood: 5-10cc whole blood lavender-top EDTA or yellow-top ACD-A tubes
- Turnaround Time: 10 business days, faster turnaround available for clinical trials.
REFERENCES: 1. Kroon, L. A. (2007). Drug interactions with smoking. American Journal of Health-System Pharmacy,64(18), 1917-1921. doi:10.2146/ajhp060414