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Home / Test Menu / CYP2B6

CYP2B6 Genotyping

Genelex CYP2B6CYP2B6 metabolizes about 10% of all drugs in current clinical use. There is strong evidence that certain genetic variants may affect the metabolism of efavirenz (Sustiva®), bupropion (Wellbutrin SR®), and methadone (Dolophine®).[40] Patients who are initiating these therapies, or have a history of adverse effects or treatment failure, should be considered for CYP2B6 genotyping. CYP2B6 is primarily expressed in the liver and is involved in the first-pass metabolism of ingested drugs. It has also been detected in several tissues outside the liver, including the brain, kidney, and intestine. [41] Clinically relevant genetic alleles tested for CYP2B6 are *2,*4,*5,*6,*7,*9,*16,*18, and *28.

Indication for CYP2B6 Testing

Patients with a personal or family history of adverse drug reactions or treatment failures to efavirenz, bupropion, methadone, or other medications metabolized by CYP2B6 are good candidates for testing. CYP2B6 genotyping is also useful to confirm or rule out the presence of genetic variations that may impact how a patient will metabolize the medications above.

Testing may potentially allow prescribers to optimize efavirenz therapy, better predict bupropion efficacy, and identify methadone users at increased risk of developing QTc prolongation.

Insurance Coverage

CPT Codes is 81479 (provided as guidance only).

Specimen Collection

Click here to order testing supplies or call Client Services at 800-837–8362.

  • Buccal Swabs: 4 sterile buccal swabs (preferred)
  • Blood: 5-10cc whole blood lavender-top EDTA or yellow-top ACD-A tubes
  • Turnaround Time: 10 business days, faster turnaround available for clinical trials

Individual Genes Tested

CYP2C9
CYP2C19
CYP2D6
CYP3A4 / CYP3A5
ADRA2A
CYP1A2
CYP2B6
CYP4F2 / VKORC1
COMT
DPYD
Factor II - Factor V Leiden
GRIK4
HLA-A or HLA-B
HTR2A
HTR2C
IFNL3
MTHFR
NAT2
OPRM1
SLCO1B1
TPMT
UGT1A1

Improving Drug Efficacy

Genelex's pharmacogenetic testing bridges the gap in understanding how the role of PGx can help in patient care and offers a simple DNA test and provides you with a report of the results that you and your doctor can discuss.

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