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Home / Test Menu / CYP2C19

CYP2C19 Genotyping

CYP2C19 acts on 5-10% of drugs in current clinical use. About 3-6% of individuals of European & African origin, as well as 13-23% of Asians, have a slow acting, poor metabolizer form of this enzyme. [31] However, there is wide variability among populations. For example, the percent of Polynesians who are poor metabolizers ranges from 38-79% depending on location.

Genelex Genotyping CYP2C19CYP2C19 is an important drug metabolizing enzyme that catalyzes the biotransformation of many other clinically useful drugs including antidepressants, barbiturates, proton pump inhibitors, antimalarial, and antitumor drugs.

Genelex offers improved detection rates using extended CYP2C19 testing. CYP2C19 testing identifies 11 of the more common alleles (*2-*10,*12,*17) in PCR-multiplex format, providing increased sensitivity and quality performance. This CYP2C19 detection panel is the most extensive on the market and covers seven known poor metabolizer alleles and one known rapid metabolizer allele. Analytical specificity and sensitivity for detection of these mutations are >99%.

Indication for CYP2C19 Testing

For individuals with a personal or family history of adverse drug reactions to medications metabolized by CYP2C19. In these cases, it's critical to confirm the presence of genotypes that affect the metabolism of drugs such as clopidogrel (Plavix®), that are metabolized by cytochrome CYP2C19.

Insurance Coverage

CPT Code is 81227 (provided as guidance only).

Specimen Collection

Click here to order testing supplies or call Client Services at 800-837–8362.

  • Buccal Swabs: 4 sterile buccal swabs (preferred)
  • Blood: 5-10cc whole blood lavender-top EDTA or yellow-top ACD-A tubes
  • Turnaround Time: 10 business days, faster turnaround available for clinical trials

Individual Genes Tested

CYP2C9
CYP2C19
CYP2D6
CYP3A4 / CYP3A5
ADRA2A
CYP1A2
CYP2B6
CYP4F2 / VKORC1
COMT
DPYD
Factor II - Factor V Leiden
GRIK4
HLA-A or HLA-B
HTR2A
HTR2C
IFNL3
MTHFR
NAT2
OPRM1
SLCO1B1
TPMT
UGT1A1

Improving Drug Efficacy

Genelex MedMPact bridges the gap in understanding how the role of PGx can help in patient care and offers a simple DNA test and provides you with a report of the results that you and your doctor can discuss.

Order Your Test

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