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Home / Test Menu / CYP3A4/CYP3A5

CYP450 3A4 / 3A5 Genotyping

Cytochrome P450 3A4 / 3A5 GenotypingCytochrome P450 3A4/5 (CYP3A4/3A5) acts on approximately half of all drugs in clinical use. About 8% of Caucasians have a slow acting, intermediate metabolizer form of CYP3A4 (CYP3A4 *22). [34]

Prevalence of CYP3A5 variants differs widely by ethnic origin. Approximately 11-12% of Asian and African Americans have non-functional CYP3A5 alleles (CYP3A5 *6, *7). CYP3A4 and CYP3A5 are closely related and may process many of the same drugs. Substrates include opioid pain medications, statins, chemotherapeutic drugs, and combined oral contraceptives.[35]

Genelex offers improved detection rates using a Cytochrome P450 3A4 mutation panel and a Cytochrome P450 3A5 DNA test. These tests each identify common clinically relevant alleles in their respective genes (CYP3A4: *1B,*22. CYP3A5: *3,*6,*7) in PCR-multiplex format. Analytical specificity and sensitivity for detection of these mutations are >99%.

Genelex offers improved detection rates using a Cytochrome P450 3A4 mutation panel and a Cytochrome P450 3A5 DNA test. These tests each identify one clinically-relevant single nucleotide variant in their respective genes in PCR-multiplex format. Analytical specificity and sensitivity for detection of these mutations are >99%.

Indication for CYP3A4/CYP3A5 Testing

For individuals with a personal or family history of adverse drug reactions to medications metabolized by CYP3A4/3A5.

Insurance Coverage

CPT Codes: CYP3A4 and CYP3A5 Mutation DNA Analysis: 81230; 81231 (provided as guidance only).

Specimen Information

Please call Client Services at 800-837-8362 to order testing supplies.

  • Buccal Swabs: 4 sterile buccal swabs (preferred)
  • Blood: 5-10cc whole blood lavender-top EDTA or yellow-top ACD-A tubes
  • Turnaround Time: 10 business days, faster turnaround available for clinical trials

Additional Info

If you would like to learn more about CYP3A4/CYP3A5, click here to view the short webinar from YouScript, Introducing CYP3A4 and CYP3A5 to the DNA sensitivity testing panel.

Individual Genes Tested

CYP2C9
CYP2C19
CYP2D6
CYP3A4 / CYP3A5
ADRA2A
CYP1A2
CYP2B6
CYP4F2 / VKORC1
COMT
DPYD
Factor II - Factor V Leiden
GRIK4
HLA-A or HLA-B
HTR2A
HTR2C
IFNL3
MTHFR
NAT2
OPRM1
SLCO1B1
TPMT
UGT1A1

Improving Drug Efficacy

Genelex's pharmacogenetic testing bridges the gap in understanding how the role of PGx can help in patient care and offers a simple DNA test and provides you with a report of the results that you and your doctor can discuss.

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(800) 837-8362
info@genelex.com

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Seattle, WA 98121

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