• Skip to primary navigation
  • Skip to main content
  • Skip to footer
Invitae | Genelex

Invitae | Genelex

Pharmacogenetics Makes Precision Medicine Possible

  • For Patients
    • Conditions
    • Affected Drugs
    • What is PGx?
    • Resources
    • FAQs
  • For Providers
    • Conditions
    • Resources
    • Order Testing Supplies
  • Test Menu
  • Clinical Trials
  • About
    • Lab Accreditations
    • Genelex Team
    • Contact Us
  • Log In
Home / Test Menu / Factor II – Factor V Leiden

Factor II and Factor V (Leiden) Genotyping

Genelex Factor II and Factor V genotypingFactor V and II are blood clotting proteins. Variations in these proteins may increase the risk of dangerous cardiovascular events caused by venous thrombosis. In clinical studies, it has been shown that several genetic defects are associated with increased risk of venous thrombosis.[47] Physicians should consider testing any patient who has had a personal or family history of such events or those at high clinical risk of venous thrombosis, including patients taking medications that are potential contributors. Genetic variants tested are Factor II: c.*97G>A (g.20210G>A) and Factor V Leiden: c.1601G>A (c.1691G>A).

Indications for Factor II and Factor V Mutation Testing

Individuals with a personal or family history of first or recurrent venous thrombosis; who have had venous thrombosis at a young age (less than 50), venous thrombosis in unusual sites (hepatic, mesenteric, cerebral veins) or venous thrombosis in pregnancy; or with a combination of those who are also taking medications which individually increase the risk for venous thrombosis.

Insurance Coverage

CPT Codes: 81241 and 81240 (provided for your guidance only).

Specimen Information

Please call Client Services at 800-837-8362 to order testing supplies.

  • Buccal Swabs: 4 sterile buccal swabs (preferred)
  • Blood: 5-10cc whole blood lavender-top EDTA or yellow-top ACD-A tubes
  • Turnaround Time: 10 business days, faster turnaround available for clinical trials

Clinical Significance

Variants to Factor V and Factor II may affect a patient’s risk of blood clotting problems. The Factor V variant known as Factor V Leiden (or rs6025) is associated with an approximately 300% increased risk in heterozygotes and an up to 8000% increased risk in homozygotes. The Factor II rs1799963 polymorphism (or G20210A) may also independently increase the risk by approximately 200%. [2]

Factor V testing is clinically actionable and recommended by the American College of Medical Genetics with Factor II as a tandem test. Patients should be counseled about the implications of their results by their physician or genetic counselor.

Prevalence

Certain polymorphisms show differing prevalence based on ethnic background.

Frequency of Factor II and Factor V Alleles with Clinical Relevance

Ethnicity
Gene Allele Enzyme Activity Caucasian African Hispanic Native American Asian
Factor V Leiden (rs6025) Decreased 2 – 5% 1.23% 2.21% 0.45% 1.25%
Factor II rs1799963 Decreased 2.2% 0.3-0.6% 2.2% rare rare

Individual Genes Tested

CYP2C9
CYP2C19
CYP2D6
CYP3A4 / CYP3A5
ADRA2A
CYP1A2
CYP2B6
CYP4F2 / VKORC1
COMT
DPYD
Factor II - Factor V Leiden
GRIK4
HLA-A or HLA-B
HTR2A
HTR2C
IFNL3
MTHFR
NAT2
OPRM1
SLCO1B1
TPMT
UGT1A1

Improve drug efficacy and start feeling better, faster

Genelex offers a simple, affordable DNA test and provides you with a report that you and your doctor can use to determine which drugs and doses are right for you.

Order Your Test

Footer

CONTACT US

(800) 837-8362
info@genelex.com

3101 Western Ave.
Suite 100
Seattle, WA 98121

HELPFUL INFORMATION

What is PGx?
Test Menu
Conditions
Affected Drugs
FAQs
References

ABOUT GENELEX

Blog
News
Genelex Team
Lab Accreditations
Contact Us
Privacy Practices
Privacy Policy

  • Facebook
  • LinkedIn
  • RSS
  • Twitter
  • YouTube

KEEP IN TOUCH

Stay in the loop with news and updates from Genelex and be among the first to know when new tests become available.