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Home / Test Menu / GRIK4

GRIK4 Genotyping

Genelex GRIK4 GenotypingGRIK4 (glutamate receptor, ionotropic, kainate 4) is the gene that encodes KA1, a type of neurotransmitter receptor subunit that joins together with other subunits to form a glutamate receptor. These receptors are located on cells in the brain and are involved in enhancing cell-cell communication, which may play a role in major depressive disorder. This type of receptor primarily binds glutamate, a major neurotransmitter involved in developmental growth, learning and memory. Although the effect of variations in GRIK4 on KA1 function and expression are not fully known, KA1 may play a role in modulating the therapeutic effect of antidepressants. Mutations in GRIK4 may impact patients with major depressive disorder who take citalopram (Celexa®).[49] Genetic variant tested for GRIK4 is c.83-10039T>C.

Indications for GRIK4 Testing

Assessment of medical necessity for testing is ultimately up to the provider’s clinical judgment. More clinical evidence is needed to determine the range of drugs and psychiatric conditions affected by GRIK4 polymorphisms.

Insurance Coverage

The CPT code for GRIK4 testing is 81479 (provided as guidance only).

Specimen Collection

Click here to order testing supplies or call Client Services at 800-837-8362.

  • Buccal Swabs: 4 sterile buccal swabs (preferred)
  • Blood: 5-10cc whole blood lavender-top EDTA or yellow-top ACD-A tubes
  • Turnaround Time: 10 business days, faster turnaround available for clinical trials

Individual Genes Tested

CYP2C9
CYP2C19
CYP2D6
CYP3A4 / CYP3A5
ADRA2A
CYP1A2
CYP2B6
CYP4F2 / VKORC1
COMT
DPYD
Factor II - Factor V Leiden
GRIK4
HLA-A or HLA-B
HTR2A
HTR2C
IFNL3
MTHFR
NAT2
OPRM1
SLCO1B1
TPMT
UGT1A1

Improve drug efficacy and start feeling better, faster

Genelex offers a simple, affordable DNA test and provides you with a report that you and your doctor can use to determine which drugs and doses are right for you.

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