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Home / Test Menu / HTR2A

HTR2A Genotyping

Genelex HTR2A GenotypingHTR2A is a post-synaptic serotonin receptor that binds serotonin and is involved in amplification of excitatory signals to other neurons in the brain. HTR2A is located in many regions of the brain. The involvement of HTR2A in antidepressant and antipsychotic effectiveness and risk of side effects is not fully understood, however, blocking the HTR2A receptor may improve antidepressant effectiveness.[52] Some polymorphisms of this gene may decrease receptor density and activity in some areas of the brain, which may affect antidepressant and antipsychotic response and risk of adverse effects. Genetic variants tested for HTR2A are c.-998G>A (c.-1438G>A), c.614-2211T>C (c.1178G>A).

Indication for HTR2A Testing

Individuals initiating an antidepressant or antipsychotic or with a history of adverse drug effects or reactions to SSRIs (Selective Serotonin Reuptake Inhibitors) may be good candidates for HTR2A testing. Testing for HTR2A polymorphisms may help predict which patients may be more likely to experience SSRI-induced adverse effects and provide supplemental information to determine if patients will adequately respond to therapy.[53] Decisions to modify therapy should not be based solely on HTR2A polymorphisms as multiple factors in addition to the HTR2A polymorphism likely contribute to antidepressant and antipsychotic response.

Insurance Coverage

The CPT code for HTR2A testing is 81479 (provided as guidance only).

Specimen Collection

Click here to order testing supplies or call Client Services at 800-837-8362

  • Buccal Swabs: 4 sterile buccal swabs (preferred)
  • Blood: 5-10cc whole blood lavender-top EDTA or yellow-top ACD-A tubes
  • Turnaround Time: 10 business days, faster turnaround available for clinical trials

Individual Genes Tested

CYP2C9
CYP2C19
CYP2D6
CYP3A4 / CYP3A5
ADRA2A
CYP1A2
CYP2B6
CYP4F2 / VKORC1
COMT
DPYD
Factor II - Factor V Leiden
GRIK4
HLA-A or HLA-B
HTR2A
HTR2C
IFNL3
MTHFR
NAT2
OPRM1
SLCO1B1
TPMT
UGT1A1

Improving Drug Efficacy

Genelex's pharmacogenetic testing bridges the gap in understanding how the role of PGx can help in patient care and offers a simple DNA test and provides you with a report of the results that you and your doctor can discuss.

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