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Home / Test Menu / IFNL3

IFNL3 (IL28B) Genotyping

The IFNL3 (IL28B) gene encodes for the protein interferon lambda 3, a cytokine, which has antiviral, antiproliferative, and immune-modulatory properties. Cytokines are released in the presence of viruses, bacteria, or tumor cells. IFNL3 polymorphisms may indicate either a favorable or unfavorable response to treatment of Hepatitis C Virus (HCV) Genotype 1, the most common type of HCV in the U.S., with pegylated interferon-alfa2a (Pegasys®) and ribavirin (Rebetol®)  containing regimens.[56] While IFNL3 genotyping is a strong predictor of treatment response, it does not determine whether or not to treat HCV infection. Genetic variant tested for IFNL3 is rs12979860C>T.

Indications for IFNL3 Testing

IFNL3 testing may be beneficial for HCV Genotype 1 patients to help predict response to pegylated interferon-alfa and ribavirin containing treatment regimens. However, while IFNL3 genetic testing may be prognostically useful, the clinical utility of testing is still unclear because results alone do not change current HCV treatment recommendations. There may be a limited role for IFNL3 testing in decreasing treatment duration or selecting double versus triple therapy regimens, but more research in this area is needed.

Insurance Information

The CPT code for IFNL3 testing is 81283 (provided for your guidance only).

Specimen Collection

Click here to order testing supplies or call Client Services at 800-837-8362.

  • Buccal Swabs: 4 sterile buccal swabs (preferred)
  • Blood: 5-10cc whole blood lavender-top EDTA or yellow-top ACD-A tubes
  • Turnaround Time: 10 business days, faster turnaround available for clinical trials

Individual Genes Tested

CYP2C9
CYP2C19
CYP2D6
CYP3A4 / CYP3A5
ADRA2A
CYP1A2
CYP2B6
CYP4F2 / VKORC1
COMT
DPYD
Factor II - Factor V Leiden
GRIK4
HLA-A or HLA-B
HTR2A
HTR2C
IFNL3
MTHFR
NAT2
OPRM1
SLCO1B1
TPMT
UGT1A1

Improving Drug Efficacy

Genelex's pharmacogenetic testing bridges the gap in understanding how the role of PGx can help in patient care and offers a simple DNA test and provides you with a report of the results that you and your doctor can discuss.

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