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Home / Test Menu / NAT2

NAT2 Genotyping

Genelex N-Acetyltransferase 2 (NAT2) Genotyping The enzyme arylamine N-acetyltransferase 2 (NAT2) metabolizes compounds that are foreign to the body (e.g, pesticides, cancer-causing chemicals), as well as therapeutic medications. Mutations in the gene encoding NAT2 may cause a decrease in NAT2 activity, resulting in potential adverse effects. In some cases, a decrease in NAT2 activity may increase medication effectiveness (e.g., hydralazine). Isoniazid, hydralazine, and certain sulfonamides have the most evidence for variations in individuals drug response caused by NAT2 polymorphisms. These drugs are frequently used as part of the treatment for infection, tuberculosis, and cardiovascular disease.[58] Additionally, mutations in the NAT2 gene are tentatively associated with certain cancers and other disease states, but in most cases, more evidence is needed. Genetic alleles tested for NAT2 are *4,*5A-E,*5G,*5J,*6A-C,*6E,*7A,*7B,*11,*12A-D,*13,*14A-G,*19.

Indications for NAT2 Testing

Individuals who have a personal or family history of adverse effects with medications metabolized by NAT2 or who are currently undergoing or will undergo isoniazid, hydralazine, or sulfonamide (e.g., sulfamethoxazole, sulfasalazine (Azulfidine®), etc.) therapy should be considered for NAT2 testing. In general, assessment of medical necessity for testing is up to the provider’s clinical judgment.

Insurance Coverage

The CPT code for NAT2 testing is 81479 (provided as guidance only).

Specimen Information

Click here to order testing supplies or call Client Services at 800-837-8362.

  • Buccal Swabs: 4 sterile buccal swabs (preferred)
  • Blood: 5-10cc whole blood lavender-top EDTA or yellow-top ACD-A tubes
  • Turnaround Time: 10 business days, faster turnaround available for clinical trials

Individual Genes Tested

CYP2C9
CYP2C19
CYP2D6
CYP3A4 / CYP3A5
ADRA2A
CYP1A2
CYP2B6
CYP4F2 / VKORC1
COMT
DPYD
Factor II - Factor V Leiden
GRIK4
HLA-A or HLA-B
HTR2A
HTR2C
IFNL3
MTHFR
NAT2
OPRM1
SLCO1B1
TPMT
UGT1A1

Improving Drug Efficacy

Genelex's pharmacogenetic testing bridges the gap in understanding how the role of PGx can help in patient care and offers a simple DNA test and provides you with a report of the results that you and your doctor can discuss.

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